I drive on some of the worst freeways in California with uneven expansion joints, cracks and potholes.
The expansion joints seem to kind of bounce the car a bit but its definitely a damped bounce, it is not a hard shock. Cracks and minor imperfections get soaked up pretty well. Potholes are bad like in any other car, possibly made slightly worse by the small diameter of the tire but they make an entertaining game of dodge.
I have read complaints about tramlining on rain grooved roads but I haven't noticed more than a little.